Hajime Nagasu Selected Research

Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)

8/2015	Deficiency of endothelial nitric oxide signaling pathway exacerbates peritoneal fibrosis in mice.
6/2012	Endothelial dysfunction promotes the transition from compensatory renal hypertrophy to kidney injury after unilateral nephrectomy in mice.

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Hajime Nagasu Research Topics

Disease

11	Chronic Renal Insufficiency 05/2024 - 05/2009
6	Proteinuria 10/2023 - 03/2012
6	Fibrosis (Cirrhosis) 01/2020 - 12/2009
3	Inflammation (Inflammations) 01/2023 - 01/2017
3	Peritoneal Fibrosis 01/2023 - 08/2015
3	Diabetic Nephropathies (Diabetic Nephropathy) 11/2019 - 01/2016
3	Hypertrophy 06/2012 - 09/2009
2	Type 2 Diabetes Mellitus (MODY) 05/2024 - 11/2021
2	Chronic Kidney Failure (Chronic Renal Failure) 10/2023 - 12/2012
2	Kidney Diseases (Kidney Disease) 11/2021 - 01/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 08/2021 - 02/2011
2	Body Weight (Weight, Body) 01/2019 - 06/2012
2	Hypoxia (Hypoxemia) 02/2011 - 12/2009
1	IGA Glomerulonephritis (IGA Nephropathy) 10/2023
1	Disease Progression 10/2023
1	Splenomegaly 04/2021
1	Hypoalbuminemia 01/2021
1	Hyperuricemia 01/2020
1	Hyperphosphatemia 01/2020
1	Hypercalcemia (Milk Alkali Syndrome) 01/2020
1	Anemia 01/2020
1	Hyponatremia 01/2020
1	Neoplasms (Cancer) 11/2019
1	Nephrosis 11/2019
1	Glomerulonephritis 11/2019
1	Reperfusion Injury 01/2019
1	Acute Kidney Injury (Acute Renal Failure) 01/2019
1	Rhabdomyolysis 01/2019
1	Heart Failure 01/2019
1	Intellectual Disability (Idiocy) 01/2018
1	Craniofacial Abnormalities 01/2018
1	Potocki-Shaffer syndrome 01/2018
1	Diabetes Mellitus 01/2016
1	Hyperglycemia 01/2016
1	Albuminuria 01/2016
1	Melanoma (Melanoma, Malignant) 10/2014
1	Stroke (Strokes) 01/2014
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2011
1	Vascular System Injuries 01/2011
1	Sclerosis 09/2010
1	Atrophy 12/2009

Drug/Important Bio-Agent (IBA)

6	InflammasomesIBA 01/2023 - 04/2013
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 09/2009
3	Biomarkers (Surrogate Marker)IBA 10/2023 - 12/2009
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016 - 09/2009
2	Sodium-Glucose Transport ProteinsIBA 05/2024 - 01/2019
2	AntioxidantsIBA 10/2023 - 01/2019
2	AlbuminsIBA 02/2023 - 09/2010
2	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 11/2021
2	CateninsIBA 11/2021 - 01/2020
2	anti-dsDNA autoantibodyIBA 04/2021 - 01/2019
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2016 - 09/2010
2	Insulin (Novolin)FDA Link 01/2016 - 04/2011
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 08/2015 - 06/2012
2	3- (4- Amino- 5- cyclopropylpyrimidine- 2- yl)- 1- (2- fluorobenzyl)- 1H- pyrazolo(3,4- b)pyridineIBA 08/2015 - 06/2012
2	Soluble Guanylyl CyclaseIBA 08/2015 - 06/2012
2	azelnidipineIBA 03/2012 - 12/2009
1	MagnesiumIBA 03/2024
1	Immunoglobulin A (IgA)IBA 10/2023
1	CreatinineIBA 02/2023
1	CytokinesIBA 01/2023
1	SolutionsIBA 01/2023
1	Interleukin-18 (Interleukin 18)IBA 01/2023
1	Sodium-Glucose Transporter 2 InhibitorsIBA 11/2021
1	ZincIBA 01/2021
1	HematinicsIBA 01/2020
1	ElectrolytesIBA 01/2020
1	SodiumIBA 01/2020
1	ChloridesIBA 01/2020
1	dh404 compoundIBA 11/2019
1	bardoxolone methylIBA 11/2019
1	AcidsIBA 01/2019
1	Glycerol (Glycerine)FDA LinkGeneric 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	Histones (Histone)IBA 01/2018
1	VimentinIBA 08/2015
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2015
1	NucleotidesIBA 10/2014
1	Irbesartan FDA LinkGeneric 01/2014
1	Hydralazine (Apresoline)FDA LinkGeneric 01/2014
1	Estrogen ReceptorsIBA 04/2013
1	DNA (Deoxyribonucleic Acid)IBA 06/2012
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 06/2012
1	Amlodipine (Norvasc)FDA LinkGeneric 03/2012
1	Insulin-Like Growth Factor I (IGF-1)IBA 04/2011
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2011
1	Mitochondrial DNA (mtDNA)IBA 02/2011
1	8-Hydroxy-2'-DeoxyguanosineIBA 02/2011
1	myxothiazolIBA 02/2011
1	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 01/2011
1	Angiotensin Receptor AntagonistsIBA 01/2011
1	salicylhydroxamic acid (SHAM)IBA 09/2010

Therapy/Procedure

3	Nephrectomy 06/2012 - 09/2009
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2023
1	Intramuscular Injections 01/2019
1	Peritoneal Dialysis 08/2015
1	Therapeutics 08/2015
1	Extracorporeal Circulation 12/2012
1	Renal Dialysis (Hemodialysis) 12/2012
1	Sympathectomy (Sympathectomies) 09/2010